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This study aims to understand how aerobic exercise contributes to neurological recovery after ischemic stroke.

June 21, 2026Cell & BioscienceOpen Access

Aerobic exercise enhances α-tubulin lactylation and neurological recovery after ischemic stroke

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This study aims to understand how aerobic exercise contributes to neurological recovery after ischemic stroke.
Developed a mouse model of ischemic stroke and implemented aerobic exercise intervention.
Administered exogenous lactate and performed RNA-sequencing (RNA-seq) analysis.
Assessed protein lactylation levels, neuroinflammation, and neural cell proliferation.
Aerobic exercise significantly elevated α-tubulin lactylation, facilitating neurological recovery.
Neuroinflammation was attenuated in the ischemic penumbra, and neural cell proliferation promoted in the subventricular zone.
Exogenous lactate improved neurological function, neurogenesis, and synaptic plasticity in stroke-affected regions.

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Randomized trial demonstrates aerobic exercise improves neurological recovery in ischemic stroke mice, suggesting new treatment avenues.

Zhang et al. (2026) studied this question.

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