Myositis ossificans (MO) is a benign, non-neoplastic condition characterized by the heterotopic formation of mature lamellar bone within soft tissues, predominantly skeletal muscle 1,13. While its exact pathophysiology remains complex, it is widely attributed to the inappropriate differentiation of pluripotent mesenchymal progenitor cells into osteoblasts, often triggered by local trauma, burns, or central nervous system injuries 8. In addition, prolonged immobilization, particularly in patients requiring intensive care unit (ICU) hospitalization, has been recognized as an important contributing factor in the development of heterotopic ossification 6.
KAYNAK et al. (Mon,) studied this question.