Mitigating Effects of Datura stramonium and Ziziphus mauritiana on Quinalphos and Dichlorvos-induced Alterations in Rats

Objective(s): The present work was conducted to study the ameliorative effects of Datura stramonium and Ziziphus mauritiana in organophosphate (OP) (quinalphos and dichlorvos) induced toxicological changes in rats. Materials and Methods: Forty-eight adult male Wistar rats were randomly divided into eight groups, each comprising six rats. Group 1 was the untreated control group, which received 3% gum acacia suspension orally. Group 2 was given quinalphos (5.5 mg/kg) orally. Group 3 animals received dichlorvos (6 mg/kg). Group 4 animals were administered quinalphos (5.5 mg/kg) and separately D. stramonium (100 mg/kg) orally. In Group 5, animals were administered dichlorvos (6 mg/kg) and separately D. stramonium (100 mg/kg) orally. In Group 6, animals were administered quinalphos (5.5 mg/kg) and separately Z . mauritiana (100 mg/kg) orally. In Group 7, animals were administered dichlorvos (6 mg/kg) and separately Z . mauritiana (100 mg/kg) orally. In Group 8, animals were administered quinalphos (5.5 mg/kg) plus dichlorvos (6 mg/kg) and separately D. stramonium (100 mg/kg) plus Z . mauritiana (100 mg/kg) orally. A dosing interval of 6 h was maintained between the treatments. All the tissue and blood samples were collected after 14 days of the first administration. Results: Combined OP treatment increased the serum level of AST, ALT, creatinine, blood urea nitrogen, and bilirubin, which were ameliorated by both the herbal plants. There was a significant decrease in total leukocyte count (TLC) observed in quinalphos and dichlorvos in combination with D. stramonium group from the control group, whereas Z . mauritiana along with quinalphos showed a significant increase in TLC than in the quinalphos-treated group alone or in combination with D. stramonium . Conclusion: The study concludes that both D. stramonium and Z . mauritiana possess ameliorative potential against quinalphos and dichlorvos-induced toxicity in adult male Wistar rats.