Non-directed Pd/S,O-ligand-catalyzed C-H arylation improves biaryl synthesis under mild conditions.
Non-directed Pd/S,O-ligand-catalyzed C–H arylation of anisole derivatives under mechanochemical conditions is described. This ball-milling protocol employs the arene as the limiting reagent, significantly reduces the amount of HFIP needed, and operates under mild conditions, providing a greener approach to biaryl synthesis.
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Bjelopetrović et al. (2026) studied this question.
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