Evaluation of NLRP3 and Asprosin Levels in Hashimoto's Thyroiditis

Aim: The aim of the study is to evaluate how NOD-like receptor pyrin domain-containing 3 (NLRP3) and asprosin change in Hashimoto’s thyroiditis ( HT), one of the autoimmune thyroid diseases.Materials and Methods: A total of 88 people, 48 patients with a diagnosis of HT and 40 healthy volunteers who applied to the Internal Medicine and Endocrinology Polyclinics between May 2019 and September 2020, were included in the study. All data recorded in the study were evaluated using the SPSS 22.0 program.Results: There were 41 (85.0%) women and 7 (15.0%) men in the HT group, with a mean age of 31.06±5.76 years. In the control group, there were 30 (75.0%) women and 10 (25.0%) men, and their mean age was 29.47±6.31 years. Asprosin level was found to be higher in the patient group than in the control group (52.74±25.31, 34.61±13.84, p<0.001, respectively). Likewise, NLRP3 levels were higher in the patient group (227.84±107.27) than in the control group (145.94±54.83, respectively, p<0.001). A significant positive correlation was found between NLRP3 and asprosin (r:0.443 p<0.001) and CRP (r:0.361 p<0.001).Conclusions: It has been observed that NLRP3 and asprosin levels may influence glucose metabolism and inflammatory processes in patients with HT, and there is a need for more comprehensive studies that could improve diagnosis, follow-up, and treatment.