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Review examines age-related changes in cerebrospinal fluid composition in children, suggesting clinical implications for diagnosis.
Cerebrospinal fluid (CSF) is a vital biological medium that reflects the physiological and pathological processes occurring within the central nervous system. The composition of CSF undergoes significant changes during childhood due to ongoing maturation of the brain, spinal cord, and blood-brain barrier. Understanding age-specific variations in CSF biochemical and cellular parameters is essential for accurate diagnosis and management of neurological disorders in pediatric patients. This article reviews the age-related characteristics of cerebrospinal fluid composition in children, including cellular content, protein concentration, glucose levels, electrolytes, and immunological markers. The findings highlight the importance of considering age-dependent reference values when interpreting CSF laboratory results in pediatric clinical practice
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Xudoyqulova et al. (2026) studied this question.
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