From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

Jessica Cristiane da Conceição de Andrade; MD e Silva; José Luís dos Santos Sousa; Jade Liz Ferreira Mendes Souza; Carolina Melo Orrico-Ferreira; Lorena Miranda de Souza; Raphael Chagas Silva; Silvia Leticia Bispo dos Santos; Antônio Márcio Santana Fernandes; João Vitor Borges Rios; Paulo Emílio Oliveira Cruz; Vitor Lima Miranda Melo; Emília Maria Medeiros de Andrade Belitardo; Luis Gustavo Carvalho Pacheco; Carina S. Pinheiro

doi:10.1111/cea.70374

June 21, 2026Clinical & Experimental AllergyOpen Access

From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

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Key Points

The research aims to explore the therapeutic potential of Trichuris trichiura-derived protein in modulating immune responses in allergic airway disease.
C4299 was administered to allergic mice to evaluate its effects on airway Th2 cytokines and regulatory mediators.
Changes in antigen-responsive Tregs and antibody responses were measured post-treatment.
C4299 significantly reduced airway Th2 cytokines in allergic mice (exact metrics not provided).
The treatment enhanced the levels of regulatory mediators, contributing to a favorable immune response.
C4299 promoted a shift in antibody responses towards IgG2a, indicating a balanced immune response.

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Implication

Shows reduced airway cytokines in allergic mice, indicating potential therapeutic applications.

Abstract

Summary • C4299 reduced airway Th2 cytokines and enhanced regulatory mediators in allergic mice. • C4299 expanded antigen‐responsive Tregs and shifted antibody responses towards IgG2a.

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Andrade et al. (2026) studied this question.

synapsesocial.com/papers/6a3a21c7111626ef22ab6858 https://doi.org/10.1111/cea.70374

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From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

From Parasite to Therapy: Immunomodulatory Effects of a Trichuris trichiura Derived Recombinant Protein in Allergic Airway Disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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