The research aims to explore the therapeutic potential of Trichuris trichiura-derived protein in modulating immune responses in allergic airway disease.
C4299 was administered to allergic mice to evaluate its effects on airway Th2 cytokines and regulatory mediators.
Changes in antigen-responsive Tregs and antibody responses were measured post-treatment.
C4299 significantly reduced airway Th2 cytokines in allergic mice (exact metrics not provided).
The treatment enhanced the levels of regulatory mediators, contributing to a favorable immune response.
C4299 promoted a shift in antibody responses towards IgG2a, indicating a balanced immune response.
Abstract
Summary • C4299 reduced airway Th2 cytokines and enhanced regulatory mediators in allergic mice. • C4299 expanded antigen‐responsive Tregs and shifted antibody responses towards IgG2a.