Why the study?
Does adjuvant radiotherapy induce subclinical cardiac changes in patients with early breast cancer?
Does adjuvant radiotherapy induce subclinical cardiac changes in patients with early breast cancer?
Adjuvant radiotherapy and aromatase inhibitor use in early breast cancer patients are associated with subclinical declines in cardiac function over 3 years.
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Subclinical cardiac changes post-RT may warrant monitoring in left-sided patients; leaves open AI effects pending prospective confirmation.
During the 3-year follow-up after RT, negative subclinical changes in cardiac biomarkers and in LV systolic and diastolic function were observed. The measured changes were more pronounced in left-sided patients. In addition, AI use was associated with impaired cardiac systolic function.
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Skyttä et al. (2019) studied this question.
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