Why the study?
FFR can produce false negative results when stenosis is relatively small, while EIS specifically distinguishes lipid-rich pools in rupture-prone plaques.
Does a novel dual-function intravascular catheter (EIS and FFR) improve diagnostic accuracy for atherosclerosis in a live pig model?
Does a novel dual-function intravascular catheter (EIS and FFR) improve diagnostic accuracy for atherosclerosis in a live pig model?
A novel dual-function intravascular catheter combining EIS and FFR was validated in a live pig model, showing potential to enhance diagnostic accuracy for rupture-prone atherosclerotic plaques.
Dual EIS-FFR catheter shows preclinical feasibility for plaque assessment; leaves open human translation and clinical utility.
We herein present a novel intravascular catheter, with dual-functions of electrical impedance spectroscopy (EIS) and flow fraction reserve (FFR), validated in live pig animal for atherosclerosis/plaques diagnostics. FFR has been the standard tool in determining plaque vulnerability yet could produce false negative results when stenosis is relatively small. Meanwhile, EIS has been demonstrated to specifically distinguish the lipid-rich pool, the signifying feature of rupture-prone plaques. The synergetic performance of these two functionalities can significantly enhance state-of-art diagnostics accuracy for atherosclerosis.
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Luo et al. (2019) studied this question.
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