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June 24, 2026Medicine InternationalOpen Access

Regenerative and molecular therapies show promise for cardiac repair but await successful clinical translation.

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Population

Patients with myocardial infarction and subsequent heart failure

Design

Review

Key result

Regenerative and molecular therapies have shown encouraging effects on cardiac repair, but successful clinical translation remains a work in progress.

Authors

DPDivina PuthooranATAdlin TomAAAnna Anna

Discussion

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Overview

Encourages sustained research investment in regenerative therapies; leaves open clinical translation pending resolution of key barriers.

Key Points

  • This review aims to summarize the current approaches in regenerative and molecular therapies for myocardial repair after myocardial infarction.
  • Narrative overview of current regenerative strategies, including gene and RNA therapeutics, cell-based therapies, and engineered cardiac patches.
  • Discussion of early clinical trial outcomes related to mesenchymal stromal cells and bone marrow-derived mononuclear cells.
  • Evaluation of advancements in induced pluripotent stem cells and pharmacological strategies for post-myocardial infarction management.
  • Early trials showed modest improvements in left ventricular function with mesenchymal stromal cells, primarily due to immunomodulatory effects.
  • Recent approaches, such as induced pluripotent stem cell-derived cardiomyocytes, show promise but face challenges like arrhythmogenic risk.
  • Gene therapies demonstrate inconsistent clinical outcomes, emphasizing the need for precise vector design and targeting.

Structured PICO

P
Population
Patients with myocardial infarction and subsequent heart failure
I
Intervention
Regenerative, molecular, and bioengineering-based therapies (including gene and RNA therapeutics, cell-based therapies, extracellular vesicles, engineered cardiac patches, and pharmacological strategies)

Regenerative and molecular therapies offer promising avenues for myocardial repair post-infarction, though significant barriers like arrhythmogenesis and scalability must be overcome for clinical application.

Limitations

  • arrhythmogenic risk
  • immunological rejection
  • scalability
  • long-term durability
  • inconsistent clinical outcomes

Cite This Study

Puthooran et al. (2026) conducted a review in myocardial infarction. Regenerative and molecular therapies was evaluated. Regenerative and molecular therapies have shown encouraging effects on cardiac repair, but successful clinical translation remains a work in progress.

synapsesocial.com/papers/6a3c235fd15afadd906fa0b0https://doi.org/10.3892/mi.2026.326
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