Key result
Extracellular matrix stiffness drives organ fibrosis by translating mechanical cues into persistent fibrotic memory.
Design
Review
Highlights the mechano-epigenetic axis as a key driver of persistent fibrotic memory in organ fibrosis.
Extracellular matrix stiffness drives fibrosis via DNA methylation, histone modifications, and non-coding RNAs. These epigenetic nodes translate mechanical cues into persistent fibrotic memory. This forum article consolidates recent advances in this mechano-epigenetic axis.
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Zhao et al. (2026) studied this question. Extracellular matrix stiffness drives organ fibrosis by translating mechanical cues into persistent fibrotic memory through DNA methylation, histone modifications, and non-coding RNAs.
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