Three-dimensional dual-energy X-ray absorptiometry (3D-DXA) parameters strongly correlated with quantitative computed tomography (QCT) across all datasets (correlation coefficients 0.82-0.97).
Cross-Sectional (n=531)
Yes
Does 3D-DXA accurately estimate proximal femur cortical and trabecular bone parameters compared to QCT in diverse populations?
3D-DXA provides accurate estimates of proximal femur bone parameters compared to QCT across diverse international cohorts.
Effect estimate: Correlation coefficients 0.82-0.97
Three-dimensional dual-energy X-ray absorptiometry (3D-DXA) reconstructs proximal femur models from standard scans to estimate cortical and trabecular bone parameters. The aim of this study was to evaluate 3D-DXA against quantitative computed tomography (QCT) across independent international cohorts. The study included 531 subjects from four cohorts: an adult population from Spain, a postmenopausal female population from the United States, an osteoarthritis population and a young population, both from Japan. Subjects underwent both 3D-DXA and QCT imaging. Accuracy was assessed using linear regression and Bland-Altman analysis to evaluate systematic and random errors. 3D-DXA parameters strongly correlated with QCT across all datasets, with correlation coefficients between 0.82 and 0.97. Random errors were consistent across cohorts and ranged between 16.55 and 19.91 mg/cm
Bracco et al. (Mon,) conducted a cross-sectional in Bone parameter evaluation (n=531). Three-dimensional dual-energy X-ray absorptiometry (3D-DXA) vs. Quantitative computed tomography (QCT) was evaluated on Correlation of cortical and trabecular bone parameters between 3D-DXA and QCT (Correlation coefficients 0.82-0.97). Three-dimensional dual-energy X-ray absorptiometry (3D-DXA) parameters strongly correlated with quantitative computed tomography (QCT) across all datasets (correlation coefficients 0.82-0.97).