What is the clinical evidence from this study?

Study design: Other. Population: Cardioprotection in rat cardiomyocytes.

What question did this study set out to answer?

This article is retracted due to concerns about image duplications and potential research integrity issues.

June 24, 2026Canadian Journal of Cardiology0 citations

Retraction notice for “MicroRNA-133b-5p Is Involved in Cardioprotection of Morphine Preconditioning in Rat Cardiomyocytes by Targeting Fas” Canadian Journal of Cardiology, Volume 32, Issue 8, August 2016, Pages 996-1007. doi:10.1016/j.cjca.2015.10.019

Q: What does this research mean for the field?

The previously published article regarding the role of MicroRNA-133b-5p in morphine preconditioning has been retracted due to concerns regarding potential duplications in flow cytometry and western blot images. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

SHShufang HeAnhui Medical University HZHaijuan ZhuAnhui Medical University ZHZhengyi HanAnhui Medical University

Key Result

The article investigating microRNA-133b-5p in morphine preconditioning of rat cardiomyocytes was retracted due to concerns regarding potential duplications in flow cytometry and western blot images.

Key Points

This article is retracted due to concerns about image duplications and potential research integrity issues.
Concern raised about flow cytometry images in Figures 5 and 7.
Issues identified with western blot bands in Figures 6 and 8.
Authors contacted for clarification regarding the discrepancies.
Article retraction confirmed following investigation into reported issues.
Duplications in several figures questioned the validity of the findings.
Journal policy enforcement led to the withdrawal of the publication.

Structured PICO

Population

Rat cardiomyocytes

Intervention

Morphine preconditioning

This is a retraction notice for a previously published article due to image duplication concerns.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). Post-publication, the journal was alerted to concerns about potential duplications between the flow cytometry images shown in Figures 5 and 7, as well as the western blot bands shown in Figures 6 and 8. These concerns were also raised on PubPeer (https://pubpeer.com/publications/A3E400704B0FACB79EDAE1DDEE1662). The journal reached out to the authors for an explanation.

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