March 1, 2001Journal of Cardiovascular Electrophysiology
Breakthrough Waves During Ventricular Fibrillation Depend on the Degree of Rotational Anisotropy and the Boundary Conditions: A Simulation Study
Key result
In a simulated model of ventricular fibrillation, rotational anisotropy promoted multiple scattered wavelets and breakthrough waves in the left ventricle, but comparatively few in the right ventricle.
Why the study?
Does rotational anisotropy affect the dynamics of scroll waves and genesis of breakthrough waves during ventricular fibrillation in simulated ventricular wall slabs?
Population
Simulated three-dimensional ventricular wall slabs (LV 10 mm, RV 5 mm) using Luo-Rudy phase I equations
Comparison
Incorporation of rotational anisotropy vs No rotational anisotropy (0 degrees)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Highlights potential LV-RV differences in VF wave dynamics; leaves open clinical translation of anisotropy effects.
Structured PICO
Does rotational anisotropy affect the dynamics of scroll waves and genesis of breakthrough waves during ventricular fibrillation in simulated ventricular wall slabs?
P
Population
Simulated three-dimensional ventricular wall slabs (LV 10 mm, RV 5 mm) using Luo-Rudy phase I equations
E
Exposure
Incorporation of rotational anisotropy (twisted LV model: 60 and 120 degrees; twisted RV model: 30 and 60 degrees)
C
Comparator
No rotational anisotropy (0 degrees)
O
Outcome
Scroll wave behavior and genesis of breakthrough waves during ventricular fibrillationsurrogate
Computational modeling demonstrates that the proportion of electrical effects of rotational anisotropy and tissue boundaries plays an important role in the genesis of breakthrough waves during ventricular fibrillation, differing between LV and RV.
Cite This Study
Ashihara et al. (2001) studied Ventricular fibrillation. Rotational anisotropy in simulated ventricular wall slabs vs. No rotational anisotropy was evaluated on Scroll wave behavior and breakthrough waves. In a simulated model of ventricular fibrillation, rotational anisotropy promoted multiple scattered wavelets and breakthrough waves in the left ventricle, but comparatively few in the right ventricle.