Key result
Cigarette smoking is linked to more than double the coronary event rate of non-smokers.
Why the study?
Does smoking increase the risk of coronary heart disease and alter intermediate risk factors in a general population cohort?
Population
30,908 participants enrolled between 1978 and 1995 in the Münster Heart Study.
Comparison
Smoking (36% of men and 32% of women). vs Non-smoking.
Design
Cohort
Follow-up
8 years (for the subgroup of 4,639 men)
Authors
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Supports smoking cessation in middle-aged adults; leaves open whether lipids/fibrinogen mediate the doubled event rate in this cohort.
Cohort (n=30,908)
Does smoking increase the risk of coronary heart disease and alter intermediate risk factors in a general population cohort?
Smoking is associated with adverse changes in lipids and fibrinogen, but these changes explain only a small part of the doubled coronary heart disease risk observed in smokers.
Paul Cullen (1998) conducted a cohort in Coronary heart disease (n=30,908). Smoking vs. Non-smokers was evaluated on Coronary event rate (definite myocardial infarction, sudden cardiac death). Cigarette smoking was associated with adverse lipid and fibrinogen changes and a coronary event rate more than twice that of non-smokers over 8 years of follow-up.
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