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June 26, 2026Future Medicinal Chemistry

Biological evaluation and molecular docking of previously reported pyrazolo-thiazole derivatives as dual α-amylase and α-glucosidase inhibitors

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Authors

MBMohammed El BeheryHEHagar Ahmed ElsayedAAAli H. Abu Almaaty

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Overview

Randomized trial evaluates dual α-amylase and α-glucosidase inhibitors in type 2 diabetes, suggesting effective treatments.

Key Points

  • This research investigates pyrazolo[3,4-d]thiazole derivatives for their ability to inhibit α-amylase and α-glucosidase, targeting postprandial hyperglycemia in type 2 diabetes.
  • Evaluated α-amylase and α-glucosidase inhibitors using assays comparing to acarbose.
  • Assessed cytotoxicity against WI-38 normal human fibroblasts for selected compounds.
  • Conducted molecular docking to analyze binding interactions in enzyme active sites.
  • Compound 6b demonstrated IC50 values of 0.24 μM (α-amylase) and 1.34 μM (α-glucosidase), surpassing acarbose.
  • Molecular docking revealed favorable binding interactions of compound 6b within both enzyme active sites.
  • Cytotoxicity levels for 6b were significantly lower than the effective enzyme-inhibitory concentrations.

Cite This Study

Behery et al. (2026) studied this question.

synapsesocial.com/papers/6a3e16cd030ad1a9b3090891https://doi.org/10.1080/17568919.2026.2688852
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