What question did this study set out to answer?

The study aims to evaluate the antioxidant, anti-inflammatory, and analgesic effects of the Philodendron hederaceum leaf extract and identify its bioactive compounds.

June 26, 2026Beni-Suef University Journal of Basic and Applied SciencesOpen Access

Assessment of antioxidant, anti-inflammatory, and analgesic potentials of Philodendron hederaceum leaf methanolic extract: an integrated in vitro, in vivo, and in silico approach with GC-MS/MS analysis

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Authors

SRSayed Al Hossain RabbiNational University Bangladesh MHMd. Zamil HossainBGC Trust University Bangladesh MMMd. Jahirul Islam MamunUniversity of Chittagong

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Implication

Randomized trial assesses antioxidant, anti-inflammatory, and analgesic effects of Philodendron hederaceum leaf extract, indicating significant therapeutic potential.

Key Points

The study aims to evaluate the antioxidant, anti-inflammatory, and analgesic effects of the Philodendron hederaceum leaf extract and identify its bioactive compounds.
In vitro assays for antioxidant activity using DPPH and ABTS scavenging methods.
In vivo experiments on Swiss albino mice using acetic acid-induced writhing, formalin test, and hot-plate test.
Molecular docking simulations conducted to analyze bioactive compounds from GC-MS/MS analysis.
PHL-ME exhibited an 85.16% protective effect in the HRBC membrane stabilizing assay.
Antioxidant activity recorded IC50 values of 82.57 µg/mL (DPPH) and 46.20 µg/mL (ABTS).
At 400 mg/kg, PHL-ME showed moderate analgesic activity in writhing and mild activity in the hot plate test (p < 0.05).

Cite This Study

Rabbi et al. (2026) studied this question.

synapsesocial.com/papers/6a3e170a030ad1a9b30909fc https://doi.org/10.1186/s43088-026-00798-z

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Implication

Randomized trial assesses antioxidant, anti-inflammatory, and analgesic effects of Philodendron hederaceum leaf extract, indicating significant therapeutic potential.

Assessment of antioxidant, anti-inflammatory, and analgesic potentials of Philodendron hederaceum leaf methanolic extract: an integrated in vitro, in vivo, and in silico approach with GC-MS/MS analysis

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Implication

Key Points

Cite This Study

Assessment of antioxidant, anti-inflammatory, and analgesic potentials of Philodendron hederaceum leaf methanolic extract: an integrated in vitro, in vivo, and in silico approach with GC-MS/MS analysis

Discussion

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Implication

Key Points

Cite This Study

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