Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

Sadullah Toprak; Murat Arı; Hatice Feray Arı; İsmail Koyuncu

doi:10.69601/meandrosmdj.1927246

June 23, 2026Meandros Medical And Dental JournalOpen Access

Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

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Key Points

This study evaluates the diagnostic utility of inflammasome-related biomarkers NLRP3, caspase-1, and IL-18 in pediatric sepsis.
Prospective case–control study with 60 pediatric patients admitted to the PICU from November 2022 to January 2023.
Included 30 patients with sepsis and 30 non-septic controls, measuring serum levels of biomarkers through ELISA within 48 hours of diagnosis.
Collected demographic, clinical, laboratory, and PRISM III data for comparison between groups.
NLRP3 levels were significantly higher in the sepsis group compared to controls (p < 0.001).
Caspase-1 levels were significantly elevated in pediatric sepsis patients (p < 0.001).
IL-18 levels were found to be significantly increased in the sepsis group compared to non-septic controls (p < 0.001).

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Implication

Prospective case-control study evaluates NLRP3, caspase-1, and IL-18 for their diagnostic utility in pediatric sepsis, suggesting their importance in early diagnosis.

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Cite This Study

Toprak et al. (2026) studied this question.

synapsesocial.com/papers/6a3e1799030ad1a9b3090fdb https://doi.org/10.69601/meandrosmdj.1927246

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Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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