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Systematic review analyzes pharmacokinetics of ceftriaxone in various animal species, highlighting key inconsistencies.
BACKGROUND: Ceftriaxone is an antibiotic frequently prescribed in veterinary medical practice due to its effectiveness against several pathogenic microorganisms responsible for diseases in different animal species. OBJECTIVE: To select scientific articles from the academic databases PubMed and Web of Science that analysed the pharmacokinetic aspects of intravenously administered ceftriaxone in animals. METHODS: In accordance with the principles of scientific transparency, the systematic review protocol and all research stages were previously registered on the Open Science Framework (OSF) platform. The scientific articles that met the inclusion criteria were subjected to a checklist comprising 24 minimum assessment items designed for reporting pharmacokinetic studies. RESULTS: A total of 52 pharmacokinetic profiles were identified from the 29 selected scientific articles, including records involving 13 different animal species used in ceftriaxone experimental studies. CONCLUSION: The limitations and inconsistencies identified in this review highlight the importance of detailed reporting of pharmacokinetic data derived from experimental trials in animals.
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Vasconcelos et al. (2026) studied this question.
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