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Research Article demonstrates the use of DNA and peptides to construct nanopores for single-molecule sensing.
Nanopores serve as sensors for single-molecule characterization. In Research Article e3311099, Ryuji Kawano and co-workers constructed synthetic nanopores using DNA and peptides that enable single-molecule translocation. The cover illustrates that the key to pore formation is the presence of 2-aminoisobutyric acid in the peptide, while the DNA scaffold assembles the peptides into well-defined oligomeric states. Image credit: Hiroko Uchida.
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Peng et al. (2026) studied this question.
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