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Protocol enhances cardiomyocyte and endothelial cell production in human pluripotent stem cells, suggesting improved regeneration strategies.
Placental growth factor (PLGF) drives cardiomyogenesis and vasculogenesis during cardiogenesis. Here, we present a protocol for enhancing production of human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) and endothelial cells (ECs). We describe steps for CM-/EC-directed hPSC differentiation with PLGF. Our approaches can achieve production of hPSC-CMs/-ECs by 2- to 2.5-fold compared with those in traditionally established protocols, through promoting proliferation and differentiation of cardiac and vascular progenitors. For complete details on the use and execution of this protocol, please refer to Witman et al. 1
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Liu et al. (2026) studied this question.
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