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June 26, 2026Current Neuropharmacology

Recent Advances in Blood-brain Barrier (BBB)-Penetrating Nanomaterialsfor Neurological Disease Imaging, Diagnosis, and Therapy

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Authors

SLSiwen LiuLGLihua GaoCLChengxin Liu

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Overview

Review summarizes nanomaterials for BBB penetration to improve diagnosis and therapy in neurological diseases, suggesting future research directions.

Key Points

  • The aim is to explore how nanomaterials can cross the blood-brain barrier to enhance diagnosis and therapy for neurological diseases.
  • Systematic review of recent literature on BBB-penetrating nanomaterials.
  • Analysis of penetration mechanisms: receptor-mediated, adsorption-mediated, and carrier-mediated.
  • Evaluation of different types of nanomaterials: metallic, polymeric, and lipid-based.
  • Receptor-mediated penetration shows high targeting specificity and low toxicity.
  • Adsorption-mediated penetration offers broad universality and simple preparation.
  • Future research needs include intelligent responsive nanocarriers and standardized toxicity assessments.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a3e1a93030ad1a9b3092ffahttps://doi.org/10.2174/011570159x450934260313135820
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience2024 · 37 citations
  2. 2Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders2024 · 26 citations
  3. 3Cracking the Blood–Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological Therapies2025
  4. 4Nanoparticle-Based Drug Delivery Across the Blood–Brain Barrier: Current In Vivo Evidence, Translational Challenges, and Future Perspectives2026
  5. 5Innovative Nanoparticle-based Therapeutic Strategies: OvercomingBiological Barriers for Enhanced Efficacy2026