August 29, 1975Science140 citations
View Full PaperAcetaldehyde Oxidation by Hepatic Mitochondria: Decrease After Chronic Ethanol Consumption
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Abstract
Prolonged consumption of ethanol significantly reduces the capacity of rat liver mitochondria to oxidize acetaldehyde. This is associated with decreased mitochondrial respiration with acetaldehyde as substrate. The reduced ability of mitochondria to metabolize acetaldehyde may explain the high levels of acetaldehyde in the blood of alcoholics, which in turn could promote the perpetuation of liver injury.