Evaluation of oxidant stress markers in a population involved in a health care program

Unhealthy lifestyles lead to obesity, hypertension and diabetes that may contribute to oxidative stress; the latter can be evaluated through biomarkers reflecting total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative damage to lipids and proteins, measured by thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP). Lifestyle modification through healthy nutrition and regular exercise may improve these alterations. This study evaluated the effectiveness of a short-term Health Care Program (HCP) in improving anthropometric, biochemical, and oxidative stress parameters in adults from Mexico City. Outcomes were assessed at the first clinical evaluation during the program (week 8) and nine weeks later (week 16). Significant reductions were observed in body weight, body mass index (BMI), waist circumference, fasting blood glucose, and total cholesterol. In participants with abnormal baseline values (HR), systolic and diastolic blood pressure, and glycated hemoglobin also decreased. TAC and TOS levels significantly declined post-intervention. TBARS and AOPP remained unchanged, although AOPP decreased in HR-BMI participants. No significant changes in TAC, TOS, or AOPP over time were detected according to the number of metabolic risk factors; however, some descriptive patterns were observed. Overall, the HCP improved metabolic and redox parameters, highlighting its potential to reduce oxidative stress.