Key result
Decreased DNMT1 mRNA expression following IVIG treatment was significantly associated with the development of coronary artery lesions in patients with Kawasaki disease.
Why the study?
Although global DNA hypomethylation has been uncovered in Kawasaki disease, its underlying cause remains uncertain.
Are transcript levels of DNA methyltransferases and demethylases altered in children with Kawasaki disease and associated with coronary artery lesion formation?
Population
Kawasaki disease patients
Comparison
Survey of transcript levels of DNA methyltransferases and demethylases
Authors
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Enzyme transcript survey in KD may identify hypomethylation drivers; leaves open mechanistic and therapeutic implications pending validation.
Observational (n=145)
No
Are transcript levels of DNA methyltransferases and demethylases altered in children with Kawasaki disease and associated with coronary artery lesion formation?
p-value: p=0.037
Transient DNA hypomethylation, driven by decreased DNMT1 and increased TET2 expression, occurs during the acute inflammatory phase of Kawasaki disease and is associated with coronary artery lesion formation.
Huang et al. (2019) conducted an observational in Kawasaki disease (n=145). Coronary artery lesion (CAL) development vs. No coronary artery lesion development was evaluated on DNMT1 mRNA levels following IVIG treatment (p=0.037). Decreased DNMT1 mRNA expression following IVIG treatment was significantly associated with the development of coronary artery lesions in patients with Kawasaki disease.
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