Key result
Calcific aortic valve stenosis is an active biological disease process rather than a passive degenerative one, and valve replacement often leaves behind a remodeled left ventricle.
Why the study?
Understanding aortic stenosis pathophysiology as an active biological rather than passive degenerative process may aid in disease prevention.
This review highlights that calcific aortic stenosis is an active, regulated process of biomineralization and inflammation, emphasizing the need for novel medical therapies to prevent its progression.
Aortic stenosis is the most common valvular heart disease affecting the elderly. While most patients have a prolonged asymptomatic phase, the development of symptoms ushers in a phase clinical deterioration that often leads to sudden death without an intervention. Treatment of aortic stenosis with valve replacement often relieves the symptoms but still leaves behind a remodeled left ventricle which may not recover. Understanding the pathophysiology of aortic stenosis and realizing that the disease process may be a more active biological entity rather than a passive degenerative process will help us prevent it. This review serves to summarize the latest literature on the pathophysiology of aortic stenosis in the elderly.
No takes yet. Share an insight, caveat, or question.
Kodra et al. (2022) conducted a review in Aortic stenosis. Calcific aortic valve stenosis is an active biological disease process rather than a passive degenerative one, and valve replacement often leaves behind a remodeled left ventricle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: