Key result
Angiotensin-converting enzyme inhibitors exhibit unique pharmacokinetic properties due to saturable binding to ACE pools, explaining the absence of drug accumulation during repeated dosing.
Design
Review
Authors
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ACEI dosing models must incorporate saturable tissue binding; leaves open optimized regimens in veterinary cardiology.
Provides a physiologically based model to explain the unique pharmacokinetic properties of ACE inhibitors, demonstrating why they do not accumulate during repeated dosing despite a protracted terminal phase.
Toutain et al. (2004) reported a review. Angiotensin-converting enzyme (ACE) inhibitors was evaluated. Angiotensin-converting enzyme inhibitors exhibit unique pharmacokinetic properties due to saturable binding to ACE pools, explaining the absence of drug accumulation during repeated dosing.
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