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June 27, 2026Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

β-caryophyllene attenuates lead acetate-induced hepatotoxicity through regulation of oxidative stress, inflammation, and PI3K/AKT/mTOR signaling

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Authors

EKEsra Manavoğlu KirmanİBİsmail BolatTKTuba KARAARSLAN

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Overview

Randomized trial investigates β-caryophyllene's impact on liver injury from lead acetate, suggesting protective potential.

Key Points

  • This study investigates the hepatoprotective effects of β-caryophyllene against lead acetate-induced liver injury.
  • Sixty male Sprague-Dawley rats were randomly assigned to five groups: control, BCP200, PbAc, PbAc + BCP100, and PbAc + BCP200.
  • Serum liver enzymes, oxidative stress parameters, and inflammatory cytokines were evaluated.
  • Immunohistochemical analyses and qRT-PCR were performed to assess relevant signaling pathways and gene expression.
  • PbAc exposure significantly increased serum liver enzyme levels and pro-inflammatory cytokines (p<0.05).
  • BCP treatment significantly reduced oxidative stress and restored Nrf2/HO-1 signaling (p<0.01).
  • Histopathological analysis showed that BCP improved PI3K/AKT/mTOR pathway activity and reduced apoptosis markers compared to the PbAc group.

Cite This Study

Kirman et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953f023https://doi.org/10.1007/s00210-026-05605-1
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