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June 27, 2026iScienceOpen Access

Mitochondrial redox imbalance in triggering regulated cell death in kidney diseases

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Authors

WZWenping ZhuRZRan ZouRLRuotian Liu

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Overview

Review outlines how mitochondrial redox imbalance triggers cell death types in kidneys, suggesting new therapy insights.

Key Points

  • The aim is to explore how mitochondrial redox imbalance leads to various forms of regulated cell death in kidney diseases.
  • Review of literature regarding mitochondrial reactive oxygen species and their role in renal health.
  • Analysis of mechanisms linking oxidative stress and regulated cell death forms in kidney cells.
  • Evaluation of therapeutic approaches targeting mtROS for kidney disorders.
  • Mitochondrial redox imbalance leads to excessive mtROS accumulation, contributing to oxidative stress in kidney cells.
  • Oxidative stress triggers multiple regulated cell death pathways: autophagy, apoptosis, pyroptosis, ferroptosis, necroptosis, cuproptosis, and PANoptosis.
  • Understanding these processes may inform the development of new mtROS-targeted treatments for kidney diseases.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f246https://doi.org/10.1016/j.isci.2026.116405
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