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June 27, 2026CureusOpen Access

Psychiatric and cardiometabolic disorders are linked bidirectionally via overlapping inflammation and stress biology pathways.

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Why the study?

Although psychiatric disorders and cardiometabolic disease frequently coexist, the shared biological and clinical pathways linking mental illness with metabolic dysfunction remain incompletely defined.

Design

Narrative review

Key result

Psychiatric and cardiometabolic disorders are associated through bidirectional and overlapping pathways, including inflammation and stress biology, rather than a single causal mechanism.

Authors

PMPooja MohantyOdisha University of Agriculture and TechnologyMUM Sheikh Giash UddinSylhet Agricultural UniversityKSKumar SambhavAll India Institute of Medical Sciences Jodhpur

Discussion

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Overview

Supports integrated screening in comorbid patients; leaves open causal pathways for prospective trials.

Key Points

  • This review aims to explore the biological and clinical pathways linking psychiatric disorders with metabolic dysfunction.
  • Narrative review based on literature from major biomedical databases.
  • Focused on relevant shared mechanisms, clinical significance, and methodological strength.
  • Highlighted factors include inflammation, neuroendocrine dysregulation, and lifestyle influences.
  • Psychiatric and cardiometabolic disorders are associated through bidirectional pathways.
  • Metabolic dysfunction may worsen psychiatric symptoms via inflammatory and hormonal mechanisms.
  • Psychiatric illness can increase cardiometabolic risk through stress, lifestyle, and medication effects.

Structured PICO

P
Population
Patients with psychiatric disorders (depression, anxiety, schizophrenia, severe mental illness) and cardiometabolic disease

Psychiatric and cardiometabolic disorders share bidirectional pathways, highlighting the need for routine metabolic screening and integrated care in psychiatric patients.

Limitations

  • Causality between psychiatric disorders and cardiometabolic disease remains unclarified

Cite This Study

Mohanty et al. (2026) conducted a review in Psychiatric disorders and cardiometabolic disease. Shared biological and clinical pathways was evaluated. Psychiatric and cardiometabolic disorders are associated through bidirectional and overlapping pathways, including inflammation and stress biology, rather than a single causal mechanism.

synapsesocial.com/papers/6a3f6871aea7db3c1953f935https://doi.org/10.7759/cureus.111469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Psychiatric‐Metabolic Interface: Exploring the Interplay Between Mental Disorders and Metabolic Syndrome2026 · 4 citations
  2. 2Disentangling the relationship between psychiatric disorders, cardiometabolic abnormalities, and antipsychotics: A systematic review of genomic studies2026
  3. 3Metabolic syndrome in psychiatric disorders2024
  4. 4REVIEW THE CURRENT THERAPEUTIC INTERVENTIONS AND MANAGEMENT STRATEGIES THAT TARGET BOTH MENTAL HEALTH AND METABOLIC ABNORMALITIES IN INDIVIDUALS2024
  5. 5Managing metabolic syndrome in bipolar disorder: multidisciplinary monitoring and treatment strategies2026