Randomized trial evaluates a new multimorbidity model for depression in rats, suggesting herbal compounds may effectively anchor health.
Key Points
The study aims to redefine the pathogenesis of post-stress depression through a five-disease multimorbidity trajectory model.
Established B1CB2GE clusters in acute forced swimming male Sprague-Dawley rats.
Compared multimorbidity trajectories using 10 analytic methods, including pharmacokinetic-pharmacodynamic analyses.
Measured biomarkers related to oxidative, endothelial, and inflammatory impairment after BSS administration.
Distinct B1CB2GE multimorbidity clusters were identified with varying normalized ranking values: G 15.31 > B2 1.17 > B1 0.85 > C 0.49 > E 0.32.
MH demonstrated the strongest effects on improving brain-derived neurotrophic factor and cecal butyrate levels, with optimal anchoring efficiency of 96.37–104.14%.
Effects of BSS and compounds were confirmed to be ghrelin-dependent, with significant therapeutic potential.