Key result
Pharmacist-led medication therapy management resolved 69.8% of drug-related problems and significantly improved blood pressure, glucose, and lipid levels (p<0.05).
Why the study?
The study was conducted to assess therapy relative to indication, effectiveness, safety, and adherence in patients with Alzheimer's disease.
Does pharmacist-led medication therapy management improve clinical parameters and resolve drug-related problems in patients with Alzheimer's disease?
Does pharmacist-led medication therapy management improve clinical parameters and resolve drug-related problems in patients with Alzheimer's disease?
Pharmacist-led medication therapy management effectively resolves drug-related problems and improves metabolic and hemodynamic parameters in patients with Alzheimer's disease.
Answers are grounded in this paper and cite their sources.
MTM may aid DRP resolution in small cohorts; leaves open confirmation in randomized trials on outcomes.
To assess the therapy relative to indication, effectiveness, safety and adherence in patients with Alzheimer’s disease (AD). An interventional, prospective, non-randomized study was conducted in a single secondary care center in Brazil. The pharmacist-led medication therapy management (MTM) was conducted to detect drug-related problems (DRPs) at baseline and after six months of intervention. The health status outcomes (i.e. cognitive screening tests; levels of glucose; total cholesterol; triglycerides; thyroid stimulating hormone; serum free thyroxine and blood pressure) were measured. 66 patients with AD were included, of whom 55 patients completed the follow-up of six months. 36 patients (36/55) were non-adherent to AD drug therapy. Out of detected 166 DRPs, 116 were solved. Four patients were withdrawn from the AD protocol due to resolution of prodromal symptoms. On the conclusion of the study, the MTM improved and controlled blood pressure, glucose, total cholesterol, triglycerides levels (p<0.05). The pharmacist-led MTM was effective in solving 69.8% of DRPs, improving and controlling the clinical parameters evaluated.
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Forgerini et al. (2022) studied Alzheimer's disease (n=66). Pharmacist-led medication therapy management (MTM) was evaluated on Resolution of drug-related problems (DRPs). Pharmacist-led medication therapy management resolved 69.8% of drug-related problems and significantly improved blood pressure, glucose, and lipid levels (p<0.05).
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