Key result
Preoperative continuation of oral hypoglycemic drugs significantly lowered perioperative blood glucose levels compared to withholding them (mean 138 vs 156 mg/dL; P<.001).
Why the study?
Does continuing oral hypoglycemic drugs preoperatively improve perioperative blood glucose levels in ambulatory surgery patients with type 2 diabetes mellitus?
RCT (n=142)
randomized
Does continuing oral hypoglycemic drugs preoperatively improve perioperative blood glucose levels in ambulatory surgery patients with type 2 diabetes mellitus?
Continuing oral hypoglycemic drugs preoperatively in type 2 diabetic patients undergoing ambulatory surgery significantly lowers perioperative blood glucose levels compared to the standard practice of discontinuation.
Answers are grounded in this paper and cite their sources.
May support continuing oral hypoglycemics preoperatively for glycemic control; hypothesis-generating pending RCTs on outcomes.
Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95% confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95% confidence interval, 146-167 mg/dL; P < .001).
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Gasanova et al. (2018) conducted an RCT in Type 2 diabetes mellitus (n=142). Continuation of oral hypoglycemic drugs vs. Withholding oral hypoglycemic drugs was evaluated on Perioperative blood glucose levels (p=<.001). Preoperative continuation of oral hypoglycemic drugs significantly lowered perioperative blood glucose levels compared to withholding them (mean 138 vs 156 mg/dL; P<.001).
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