Key result
Cardiorespiratory fitness >9.45 metabolic equivalents and physical activity >150 minutes per week were associated with reduced risks of lung cancer mortality.
Why the study?
Lung cancer is the leading cause of cancer death, but the influence of cardiorespiratory fitness and physical activity on lung cancer mortality had not been previously investigated.
Do higher levels of cardiorespiratory fitness, physical activity, walking speed, and leisure activity reduce lung cancer mortality and all-cause mortality?
Meta-Analysis (n=6,037,058)
Do higher levels of cardiorespiratory fitness, physical activity, walking speed, and leisure activity reduce lung cancer mortality and all-cause mortality?
Moderate to high cardiorespiratory fitness and physical activity are associated with reduced risks of lung cancer mortality and all-cause mortality.
May support exercise counseling in lung cancer care; leaves open whether improving fitness reduces mortality.
BACKGROUND: Lung cancer (LC) is the most common cause of death in cancer patients. The influence of cardiorespiratory fitness (CF) and physical activity (PA) on LC mortality has not previously been investigated. OBJECTIVE: The aim of this study was to investigate through a meta-analysis the associations among CF, PA, walking speed, or leisure activity, and LC mortality and all-cause mortality. METHODS: MEDLINE and EMBASE were used to select relevant studies from January 2000 to August 2019. A total of 6 037 058 study subjects from 11 prospective cohort studies were included in this meta-analysis. Pooled relative risks were calculated using fixed and random-effects models to estimate the associations between CF and PA, and LC mortality. In addition, a subgroup analysis was conducted to investigate associations between walking speed and leisure activity, and LC morality. RESULTS: Greater than 9.45 metabolic equivalents of CF was associated with reduced LC mortality, compared with low-level CF. Participating in more than 150 minutes per week of PA reduced LC mortality. Slower and same walking speed were associated with increased all-cause mortality compared with age-matched individuals. Finally, moderately inactive and inactive levels of leisure activity increased all-cause mortality. CONCLUSIONS: Moderate to high CF and PA were each associated with reduced risks of LC mortality. In addition, slower and same walking speed, and moderately inactive and inactive levels of leisure activity were each associated with increased risks of all-cause mortality. IMPLICATIONS FOR PRACTICE: Greater than 9.45 metabolic equivalents of CF, more than 150 minutes per week of PA, fast walking speed, and keeping active should be recommended to increase LC patient survivorship.
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Junga Lee (2020) conducted a meta-analysis in Lung cancer (n=6,037,058). Cardiorespiratory fitness and physical activity vs. Low-level cardiorespiratory fitness and inactivity was evaluated on Lung cancer mortality. Cardiorespiratory fitness >9.45 metabolic equivalents and physical activity >150 minutes per week were associated with reduced risks of lung cancer mortality.
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