Key result
Endothelial barrier dysfunction induced by hypoxanthine/xanthine oxidase or copper-catalysed homocysteine oxidation is mediated solely by hydrogen peroxide generation.
Population
In vitro model of bovine aortic endothelial cells grown on polycarbonate membranes
Comparison
Hypoxanthine + xanthine oxidase, hydrogen… vs Individual components alone or untreated control
Design
Preclinical
Follow-up
90 min incubation
Authors
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Cautions against clinical translation from bovine endothelial models; leaves open H2O2 mediation in human ischemia-reperfusion injury and atherosclerosis.
Endothelial barrier dysfunction induced by hypoxanthine/xanthine oxidase or homocysteine oxidation is mediated by hydrogen peroxide, which may be relevant to ischemia-reperfusion injury and atherosclerosis.
Berman et al. (1993) studied Endothelial barrier dysfunction. Hypoxanthine and xanthine oxidase; Homocysteine and copper sulphate vs. Agents added alone was evaluated on Albumin transfer across endothelial cell monolayers. Endothelial barrier dysfunction induced by hypoxanthine/xanthine oxidase or copper-catalysed homocysteine oxidation is mediated solely by hydrogen peroxide generation.
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