A role for Fas/FasL-dependent NK-mediated cytotoxicity in infants with perinatal HIV

Q: What does this research mean for the field?

Impaired Fas/FasL signaling limits effective early immune control, indicating that Fas/FasL-dependent NK-mediated cytotoxicity plays a crucial role in shaping antiviral immunity in infants with perinatal HIV. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Akshay Iyer; Lesley de Armas; Vinh Dinh; Suresh Pallikkuth; Rajendra N. Pahwa; Paula Vaz; Maria Grazia Lain; Savita Pahwa

doi:10.1016/j.isci.2025.113637

September 24, 2025iScienceOpen Access

A role for Fas/FasL-dependent NK-mediated cytotoxicity in infants with perinatal HIV

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Key Points

The study aims to explore the role of Fas/FasL-dependent NK-mediated cytotoxicity in enhancing antiviral immunity in infants with perinatal HIV.
Analyzed transcript expression to evaluate Fas/FasL signaling in infants with perinatal HIV.
Examined the implications of impaired signaling on immune control mechanisms.
Impaired Fas/FasL signaling was observed, suggesting limitation in effective immune responses.
Findings indicate a significant role for Fas/FasL in shaping antiviral immunity in pediatric populations.

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Implication

Investigates Fas/FasL signaling and its impact on antiviral immunity in infants with perinatal HIV, suggesting new therapeutic avenues.

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Cite This Study

Iyer et al. (2025) studied this question.

synapsesocial.com/papers/6a3f919ba307ad3478fd4b31 https://doi.org/10.1016/j.isci.2025.113637

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A role for Fas/FasL-dependent NK-mediated cytotoxicity in infants with perinatal HIV

Key Points

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Implication

Abstract

Discussion

Cite This Study

A role for Fas/FasL-dependent NK-mediated cytotoxicity in infants with perinatal HIV

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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