Elevated systemic inflammation (NLR >2.5) and reduced autonomic flexibility (SDNN <30 ms) were associated with a 2.84-fold and 2.31-fold higher risk of cognitive impairment in hypertensive patients.
Cross-Sectional (n=161)
No
Are elevated neutrophil-to-lymphocyte ratio and reduced heart rate variability associated with cognitive impairment in hypertensive patients?
Elevated systemic inflammation (NLR) and reduced autonomic flexibility (SDNN) are independent predictors of cognitive decline in hypertensive patients.
Odds Ratio: 2.84
p-value: p=0.003
Background: Hypertension is a significant risk factor for cognitive decline, yet the roles of systemic inflammation and autonomic dysfunction in this progression remain poorly understood. This study aimed to evaluate the associations between the neutrophil-to-lymphocyte ratio (NLR), heart rate variability (HRV), and cognitive impairment in hypertensive patients. Methods: A cross-sectional study was conducted among 161 subjects (88 hypertensive and 73 normotensive). Cognitive function was assessed using the Hindi mini-mental state examination and the Hindi Montreal Cognitive Assessment (MoCA). Autonomic function was measured via HRV parameters, including standard deviation of normal to normal intervals (SDNN) and low-frequency power. Systemic inflammation was evaluated using the NLR. Independent predictors were identified using multivariate regression analysis. Results: Hypertensive subjects demonstrated significantly lower cognitive scores (MoCA: 24.89 ± 2.67 vs. 26.90 ± 1.78; P 140 mmHg ( P 2.5 ( P = 0.003), and 2.31 times higher with SDNN <30 ms ( P = 0.014). Conclusion: Elevated systemic inflammation (NLR) and reduced autonomic flexibility (SDNN) are independent predictors of cognitive decline in hypertensive patients. These markers, alongside SBP, provide critical prognostic value for identifying patients at high risk of cognitive impairment.
Khan et al. (Fri,) conducted a cross-sectional in Hypertension (n=161). Elevated neutrophil-to-lymphocyte ratio (NLR >2.5) vs. NLR ≤2.5 was evaluated on Cognitive impairment (OR 2.84, p=0.003). Elevated systemic inflammation (NLR >2.5) and reduced autonomic flexibility (SDNN <30 ms) were associated with a 2.84-fold and 2.31-fold higher risk of cognitive impairment in hypertensive patients.