Key result
Alpha/beta interferon priming of dendritic cells significantly inhibited early cap-dependent translation of Sindbis virus genomes through a PKR/RNase L-independent mechanism requiring de novo gene transcription.
IFN-alpha/beta inhibits Sindbis virus translation through a novel PKR/RNase L-independent pathway targeting cap-dependent translation in dendritic cells.
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IFN responses control Sindbis virus independently of PKR/RNase L; leaves open identification of primary antiviral effectors in DCs.
Ryman et al. (2005) studied Sindbis virus infection. Alpha/Beta Interferon (IFN-α/β) priming vs. Untreated cells was evaluated on Sindbis virus translation and replication (measured by luciferase activity and viral protein synthesis). Alpha/beta interferon priming of dendritic cells significantly inhibited early cap-dependent translation of Sindbis virus genomes through a PKR/RNase L-independent mechanism requiring de novo gene transcription.
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