Why the study?
Numerous studies have documented an association between psoriasis and subclinical atherosclerosis, but the effect of psoriasis on NT-proBNP and its correlation with carotid MIMT remained to be clarified.
Does moderate to severe psoriasis increase NT-proBNP and carotid intima-media thickness compared to healthy controls?
Does moderate to severe psoriasis increase NT-proBNP and carotid intima-media thickness compared to healthy controls?
In patients with moderate to severe psoriasis, NT-proBNP levels are elevated and independently correlate with carotid intima-media thickness, suggesting its potential utility as a biomarker for subclinical atherosclerosis.
Answers are grounded in this paper and cite their sources.
Elevated NT-proBNP may signal subclinical cardiac involvement in psoriasis; hypothesis-generating for future risk-stratification studies.
Background: Numerous studies have documented an association between psoriasis and subclinical atherosclerosis. Objective: We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery. Methods: Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence. Results: Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups. Conclusions: In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis.
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Niknezhad et al. (2022) studied this question.
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