Key result
Imipramine treatment in a 74-year-old man with right bundle-branch block induced a 2:1 atrioventricular block that was directly related to the drug's plasma concentration.
Why the study?
Does imipramine induce heart block in a patient with pre-existing right bundle-branch block?
Case Report (n=1)
Does imipramine induce heart block in a patient with pre-existing right bundle-branch block?
Imipramine treatment can induce concentration-dependent 2:1 atrioventricular block in patients with pre-existing right bundle-branch block.
May warrant ECG monitoring with imipramine in RBBB; single case leaves generalizability and causality open.
A 2:1 atrioventricular block developed during treatment with the tricyclic antidepressant imipramine in a 74-year-old man with a three-year history of right bundle-branch block. Serial cardiographic studies and determinations of blood imipramine concentrations showed that the heart block was directly related to the plasma concentration of the drug and occurred below the atrioventricular node in the His-Purkinje system.
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Shepard J. Kantor (1975) conducted a case report in 2:1 atrioventricular block (n=1). Imipramine was evaluated on Development of 2:1 atrioventricular block. Imipramine treatment in a 74-year-old man with right bundle-branch block induced a 2:1 atrioventricular block that was directly related to the drug's plasma concentration.
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