What is the clinical evidence from this study?

Population: Coronary artery disease (CAD). Intervention: Exercise training vs. Standard care. Primary outcome: Arterial stiffness evaluated by aortic augmentation index (p=<.05).

What question did this study set out to answer?

This research aims to evaluate the impact of exercise training on arterial stiffness in patients with coronary artery disease.

June 1, 2004American Journal of Hypertension

Effect of exercise training on central aortic pressure wave reflection in coronary artery disease*1

Q: What are the key findings of this study?

Exercise training for 12 weeks improved systemic arterial stiffness in patients with coronary artery disease, decreasing the aortic augmentation index (30% vs 26%, P<.05).

Q: What question did this study set out to answer?

This research aims to evaluate the impact of exercise training on arterial stiffness in patients with coronary artery disease.

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Key result

Exercise training for 12 weeks improved systemic arterial stiffness in patients with coronary artery disease, decreasing the aortic augmentation index (30% vs 26%, P<.05).

Why the study?

Does exercise training improve arterial stiffness in patients with coronary artery disease?

Key Points

This research aims to evaluate the impact of exercise training on arterial stiffness in patients with coronary artery disease.
12 weeks of exercise training or standard care was implemented in coronary artery disease patients.
Arterial stiffness was assessed using aortic augmentation index and time delay of the reflected wave via the SphygmoCor system.
The augmentation index decreased from 30% to 26% after exercise training (P <.05).
Deltat increased from 136 msec to 144 msec following the intervention (P <.05).

Structured PICO

Does exercise training improve arterial stiffness in patients with coronary artery disease?

Population

Patients with coronary artery disease evaluated before and after 12 weeks of either exercise training or standard care.

Intervention

Exercise training (endurance exercise) for 12 weeks

Comparator

Standard care for 12 weeks

Outcome

Arterial stiffness evaluated by aortic augmentation index and time delay of the reflected wave (Deltat) using the SphygmoCor systemsurrogate

Main Result

Absolute Event Rate: 26% vs 30%

p-value: p=<.05

Endurance exercise training for 12 weeks significantly improves systemic arterial stiffness in patients with coronary artery disease.

Discussion

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Implication

May support exercise training in CAD for stiffness; leaves open larger outcome trials before practice change.

Cite This Study

David G. Edwards (2004) studied Coronary artery disease (CAD). Exercise training vs. Standard care was evaluated on Arterial stiffness evaluated by aortic augmentation index (p=<.05). Exercise training for 12 weeks improved systemic arterial stiffness in patients with coronary artery disease, decreasing the aortic augmentation index (30% vs 26%, P<.05).

synapsesocial.com/papers/6a4064eceae9a54d59b27f6c https://doi.org/10.1016/j.amjhyper.2003.12.001

Topics

Coronary artery disease

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Effect of exercise training on central aortic pressure wave reflection in coronary artery disease*1

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Effect of exercise training on central aortic pressure wave reflection in coronary artery disease*1

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider