What question did this study set out to answer?

To evaluate whether physiological optimization using individualized PEEP affects clinical outcomes in lung cancer surgery patients.

June 28, 2026Anaesthesia

The search for the missing link between better physiology and patient outcomes

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Authors

SMSomalia MukherjeeImperial College London AEAhmed ElwakilHammersmith Hospital

Discussion

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Implication

Randomized trial shows improved intra-operative respiratory mechanics with individualized PEEP, yet raises concerns about postoperative complications.

Key Points

To evaluate whether physiological optimization using individualized PEEP affects clinical outcomes in lung cancer surgery patients.
Randomized trial evaluating electrical impedance tomography-guided individualized PEEP in lung cancer surgery patients
Comparison with fixed PEEP control at 5 cmH2O
Assessment of intra-operative respiratory mechanics and postoperative complications.
Improved intra-operative respiratory mechanics with individualized PEEP, including reduced driving pressures and better oxygenation
No reduction in postoperative pulmonary complications noted, questioning generalisability
Common postoperative complication was prolonged air leak, largely influenced by surgical technique rather than PEEP strategy.

Cite This Study

Mukherjee et al. (2026) studied this question.

synapsesocial.com/papers/6a40b8ed61bb0a67205c5569 https://doi.org/10.1111/anae.70270

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Implication

Randomized trial shows improved intra-operative respiratory mechanics with individualized PEEP, yet raises concerns about postoperative complications.