What question did this study set out to answer?

The aim is to evaluate the efficacy of various nutritional supplements on social impairment and behavioral dysregulation in children with autism spectrum disorder.

June 28, 2026BMC PsychiatryOpen Access

Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis

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Authors

LYL YangSichuan University FYFan YangGuangzhou University of Chinese Medicine QJQiaoyun JiSichuan University

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Implication

Network meta-analysis reveals varied impacts of nutritional supplements on social functioning and behavior in children with ASD, highlighting the need for further research.

Key Points

The aim is to evaluate the efficacy of various nutritional supplements on social impairment and behavioral dysregulation in children with autism spectrum disorder.
Conducted a network meta-analysis of randomized controlled trials (RCTs) searching PubMed, Embase, Web of Science, and Cochrane Library until December 20, 2025.
Included 16 RCTs with a total of 736 children with ASD, focusing on social functioning, irritability, and hyperactivity symptoms related to nutritional supplements.
Used a random-effects model to analyze data, calculating mean differences and SUCRA rankings.
Omega-3 supplementation showed a mean difference of −2.29 (95% CrI: −3.52 to −1.07) for social functioning, while Vitamin D showed −2.89 (−5.08 to −0.72), both better than usual treatment.
Probiotics were less effective compared to Omega-3 and Vitamin D in improving social outcomes, with Omega-3 vs. Probiotics showing a mean difference of −1.74.
No significant effects were observed for hyperactivity, and evidence was insufficient to recommend any supplement over usual treatment.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb8b61bb0a67205c6f10 https://doi.org/10.1186/s12888-026-08314-4

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Implication

Network meta-analysis reveals varied impacts of nutritional supplements on social functioning and behavior in children with ASD, highlighting the need for further research.

Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis

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Implication

Key Points

Cite This Study

Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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