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January 1, 1993Archivos de Prevención de Riesgos Laborales363 citationsOpen Access

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

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ANAlexander A. NeyfakhCBC M BorschGKGlenn W. Kaatz

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Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

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Neyfakh et al. (1993) studied this question.

synapsesocial.com/papers/6a4150beef8b3439f072541chttps://doi.org/10.1128/aac.37.1.128
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