Key result
Transcriptome and epigenome profiling of regenerative versus nonregenerative mouse hearts following myocardial infarction identified Ccl24 and Igf2bp3 as regulators of cardiomyocyte proliferation.
Why the study?
The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart regenerates readily, leaving the underlying molecular mechanisms to be uncovered.
Population
Regenerative and nonregenerative mouse hearts following myocardial infarction injury
Comparison
Regenerative vs nonregenerative mouse hearts
Design
Preclinical comparative transcriptome and epigenome profiling study
Follow-up
7-d time period
Authors
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Ccl24 and Igf2bp3 merit testing as therapeutic targets post-MI; extends mouse regeneration data but leaves human translation unproven.
The identification of Ccl24 and Igf2bp3 provides novel insights into the molecular basis of neonatal heart regeneration and highlights potential targets for promoting cardiac regeneration.
Wang et al. (2019) studied Myocardial infarction. Regenerative mouse hearts vs. Nonregenerative mouse hearts was evaluated on Transcriptional programs and regulators of cardiomyocyte proliferation. Transcriptome and epigenome profiling of regenerative versus nonregenerative mouse hearts following myocardial infarction identified Ccl24 and Igf2bp3 as regulators of cardiomyocyte proliferation.
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