Key result
Treatment with rt-PA versus streptokinase, with or without subcutaneous heparin, showed no significant difference in the incidence of left ventricular thrombi (28% overall).
Why the study?
Does the choice of thrombolytic agent (rt-PA vs streptokinase) or the addition of subcutaneous heparin reduce the incidence of left ventricular thrombus in patients with anterior acute myocardial infarction?
RCT (n=180)
randomized
Does the choice of thrombolytic agent (rt-PA vs streptokinase) or the addition of subcutaneous heparin reduce the incidence of left ventricular thrombus in patients with anterior acute myocardial infarction?
Neither the choice of thrombolytic agent (rt-PA vs streptokinase) nor the addition of subcutaneous heparin significantly reduced the incidence of left ventricular thrombus after anterior acute myocardial infarction.
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Neither thrombolytic choice nor heparin addition reduces left ventricular thrombi after anterior MI; confirms need for alternative prevention strategies.
Vecchio et al. (1991) conducted an RCT in anterior acute myocardial infarction (n=180). rt-PA with or without subcutaneous heparin vs. Streptokinase with or without subcutaneous heparin was evaluated on Incidence of left ventricular thrombi. Treatment with rt-PA versus streptokinase, with or without subcutaneous heparin, showed no significant difference in the incidence of left ventricular thrombi (28% overall).
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