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June 29, 2026ACS Applied Materials & InterfacesOpen Access

Spray-Pyrolyzed Hollow and Yolk–Shell CeO 2 Nanocarriers with Tunable Structure for Redox-Responsive Delivery and Gene Rescue Applications

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Authors

JPJalal PoostforooshanCCCléa ChesneauLMLaurent Michely

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Overview

Randomized trial demonstrates enhanced gene modulation in epithelial cells using redox-responsive nanocarriers.

Key Points

  • This study aims to develop mesoporous CeO2 nanoparticles with tunable structures for effective gene delivery and therapeutic applications.
  • Utilized gas-phase spray pyrolysis for synthesizing mesoporous CeO2 nanoparticles.
  • Varied precursor composition and thermal conditions to control particle morphology and internal cavity formation.
  • Evaluated biocompatibility and drug delivery efficacy using HEK293 and U2OS cell lines.
  • Functionalized MCNs exhibited enhanced Rhodamine 6G loading efficiency due to larger internal void volume.
  • Significantly improved G418 efficacy with restoration of CFTR-R553X activity in epithelial monolayers.
  • Demonstrated excellent biocompatibility in HEK293 cells, supporting safe therapeutic applications.

Cite This Study

Poostforooshan et al. (2026) studied this question.

synapsesocial.com/papers/6a420ab2f91bb43ea9191ebdhttps://doi.org/10.1021/acsami.6c07497
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