Demonstrates novel transformations in isoquinolines, suggesting new pathways for chemical synthesis.
A dual-pathway skeletal editing of isoquinolines was described. A common Tf 2 O-activated intermediate reacts with secondary amines and can be selectively directed under orthogonal conditions. Blue-light irradiation enables N-to-C transmutation to form naphthalenes, whereas microwave heating promotes cascade skeletal editing/annulation to yield benzo[ f ]quinazolines. Acetonitrile acts as a bifunctional C1 synthon, enabling stepwise N-to-C and C-to-C transformations, providing a rare route to benzo[ f ]quinazolines.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: