What question did this study set out to answer?

This review assesses the current state of human gut microbiome research and identifies barriers to its translation into clinical practice.

Translational human gut microbiome research: What are the missing pieces of the puzzle?

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Integrative translational review highlights the barriers and strategies for effective gut microbiome research application.

This review assesses the current state of human gut microbiome research and identifies barriers to its translation into clinical practice.
Reviewed four aspects: translational successes, barriers, frameworks from other disciplines, and strategies for progress.
Evaluated microbiome-targeted approaches such as faecal microbiota transplantation, probiotics, and dietary interventions.
Discussed translational principles and challenges specific to gut microbiome research.
Identified significant translational barriers, including high-dimensional variability and methodological inconsistencies.
Proposed a framework combining education and stakeholder engagement to address research gaps.
Highlighted the need for prioritizing patient and societal health needs in gut microbiome research.

Fassarella et al. (2026) studied this question.

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