What does this research mean for the field?

Pre-diagnostic use of intrauterine devices is modestly associated with increased cytotoxic T cell infiltration and terminal T cell exhaustion in ovarian tumors, whereas oral contraceptive use is associated with decreased cytotoxic T cell infiltration. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to examine how intrauterine devices and oral contraceptives are associated with tumor immune features in ovarian cancer.

June 29, 2026British Journal of CancerOpen Access

Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use

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This research aims to examine how intrauterine devices and oral contraceptives are associated with tumor immune features in ovarian cancer.
Assessed associations of IUD and OC use with tumor immune features using multiplex immunofluorescence in tissue microarrays from 24 ovarian tumors.
Utilized multivariable-adjusted beta-binomial models to estimate odds of tumor T cell positivity by contraceptive history.
High-grade serous tumors exhibited an average of 3.4% tumor cells positive for total T cells (CD3).
IUD use was modestly associated with increased cytotoxic T cell infiltration (OR:1.14, 95% CI:0.99–1.32).
OC use for ≥1 year was linked to lower odds of cytotoxic T cells (OR:0.89, 95% CI:0.79–1.00; p-het=0.008).

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Implication

Randomized trial evaluates contraceptive effects on tumor immunity in women, suggesting modulation of cancer risk.

Cite This Study

Mongiovi et al. (2026) studied this question.

synapsesocial.com/papers/6a420ba8f91bb43ea91929f9 https://doi.org/10.1038/s41416-026-03508-9

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Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use

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Discussion

Implication

Cite This Study

Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use

Key Points

Discussion

Implication

Cite This Study

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